Soluplus micelles for improving the oral bioavailability of scopoletin and their hypouricemic effect in vivo

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Enhancing oral bioavailability of quercetin using novel soluplus polymeric micelles

To improve its poor aqueous solubility and stability, the potential chemotherapeutic drug quercetin was encapsulated in soluplus polymeric micelles by a modified film dispersion method. With the encapsulation efficiency over 90%, the quercetin-loaded polymeric micelles (Qu-PMs) with drug loading of 6.7% had a narrow size distribution around mean size of 79.00 ± 2.24 nm, suggesting the complete ...

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ژورنال

عنوان ژورنال: Acta Pharmacologica Sinica

سال: 2017

ISSN: 1671-4083,1745-7254

DOI: 10.1038/aps.2016.126